Talk:Ellagic acid

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biphenyl?[edit]

It's a biphenyl (type of polyphenyl) is it not?— Preceding unsigned comment added by Tim (talk • contribs) 21 March 2007 17:21 (UTC)

Cancer research[edit]

PMID 25009751 makes the bold claim "EA can act through multiple pathways and can be used as a dietary agent for preventing and treating many common forms of cancer" - whether effectively or not it doesn't say, and seems to imply otherwise later in the conclusion. The article doesn't appear to be MEDLINE indexed. How (if at all) can this be used? Alexbrn ^{talk|contribs|COI} 05:45, 11 August 2014 (UTC)[reply]

authors are ~~not~~ Chinese... not sure they fully control the word "can". The overall thrust of the article, especially the last paragraph, says there are some promising results, but serious problems with ADMET so there is a long long way from where are now to using EA or analogs as a drug. Jytdog (talk) 05:55, 11 August 2014 (UTC) (strike "not" Jytdog (talk) 12:20, 11 August 2014 (UTC))[reply]

Agree - so pretty much in line with our article as it stands in any case. Alexbrn ^{talk|contribs|COI} 06:06, 11 August 2014 (UTC)[reply]

Assessment comment[edit]

The comment(s) below were originally left at Talk:Ellagic acid/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

Hhmmm. Seems to be inconsistent:

(1) "Triphala has three ingredients the third being Emblica officinalis These tannin bearing galls and fruits have more ellagic acid content than the other celebrated sources such as raspberries etc."

(2) "The highest levels of ellagic acid are found in raspberries, strawberries, and pomegranates."

Last edited at 15:56, 14 April 2008 (UTC). Substituted at 14:22, 29 April 2016 (UTC)

Research and health claims - Supplement focus[edit]

The current section on “Research and health claims” primarily discusses supplements and cancer-related assertions, often tied to brands with questionable medical claims. However, it’s essential to recognize the broader scientific context.

Ellagic acid, derived from ellagitannins found in fruits and nuts, exhibits antioxidant properties and potential health benefits. The Memorial Sloan Kettering Cancer Center provides a comprehensive page on ellagic acid, referencing peer-reviewed studies. Additionally, NIG and PubChem offer valuable resources. CheckerIsland (talk) 01:49, 18 May 2024 (UTC)[reply]

The "antioxidant properties" exist only in vitro at doses exceeding those of dietary intake, so are just a lab effect. There is no evidence of antioxidant effects in vivo, but rather the likely fate of dietary ellagic acid - as with all polyphenols - is that it is digested into smaller derivatives (which are not possible under current research tools to reliably track in vivo), then rapidly excreted via urine; see also this discussion.

The MSK source under For Health Professionals/Clinical Summary is noteworthy for its absence of discussion about advanced clinical trials, which do not exist. Who would fund multimillion dollar clinical research on a compound that cannot be patent protected for use as an approved drug?

For the encyclopedia, which should represent the mainstream scientific view, there are no reputable WP:MEDRS-quality reviews to add, no changes in international clinical guidelines to recommend ellagic acid for any treatment, and no national regulatory agency supporting any health claims. Zefr (talk) 02:37, 18 May 2024 (UTC)[reply]