From Wikipedia, the free encyclopedia
Cytosolic non-specific dipeptidase (EC 3.4.13.18 ) also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene .[5] [6] [7] This enzyme catalyses the hydrolysis of dipeptides, preferentially those containing hydrophobic amino acids . The human enzyme uses manganese ions as a cofactor.[8] In addition to its function as a peptidase, the enzyme also functions to generate N -lactoyl amino acids, such as N-lactoyl-phenylalanine , via the process of "reverse proteolysis".[9]
See also [ edit ]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000133313 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024644 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, et al. (February 2003). "Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase" . The Journal of Biological Chemistry . 278 (8): 6521–6531. doi :10.1074/jbc.M209764200 . PMID 12473676 .
^ "Entrez Gene: CNDP2 carnosine dipeptidase 2" .
^ Bauer K (1998). "Cytosol non-specific dipeptidase". In Barrett AJ, Rawlings ND, Woessner JF (eds.). Handbook of Proteolytic Enzymes . London: Academic Press. pp. 1520–1522.
^ "UniProt: CDNP2 - Cytosolic non-specific dipeptidase: Homo sapiens" .
^ Jansen RS, Addie R, Merkx R, Fish A, Mahakena S, Bleijerveld OB, et al. (May 11, 2015). "N-lactoyl-amino acids are ubiquitous metabolites that originate from CDNP2-mediated reverse proteolysis of lactate and amino acids" . Proceedings of the National Academy of Sciences of the USA . 112 (21): 6601–6606. Bibcode :2015PNAS..112.6601J . doi :10.1073/pnas.1424638112 . PMC 4450436 . PMID 25964343 .
External links [ edit ]
Activity Regulation Classification Kinetics Types